This study compares the efficacy of ketoprofen versus ceftiofur for managing metritis in dairy cows, offering important insights into peripartum bovine health management. Evaluating these inflammatory and infectious outcomes as part of the broader transition period remains critical for herd stability. For those interested in a more comprehensive perspective on these interconnected systemic challenges, a relevant section is available in The Peripartum Cow Practical Notes by Manuel Fernández, Manuel Liz, and Matilde Hernández.